Hang Jung Ling

Color Doppler echocardiography enables visualization of blood flow within the heart. However, the limited frame rate impedes the quantitative assessment of blood velocity throughout the cardiac cycle, thereby compromising a comprehensive analysis of ventricular filling. Concurrently, deep learning is demonstrating promising outcomes in post-processing of echocardiographic data for various applications. This work explores the use of deep learning models for intracardiac Doppler velocity estimation from a reduced number of filtered I/Q signals. We used a supervised learning approach by simulating patient-based cardiac color Doppler acquisitions and proposed data augmentation strategies to enlarge the training dataset. We implemented architectures based on convolutional neural networks. In particular, we focused on comparing the U-Net model and the recent ConvNeXt models, alongside assessing real-valued versus complex-valued representations. We found that both models outperformed the state-of-the-art autocorrelator method, effectively mitigating aliasing and noise. We did not observe significant differences between the use of real and complex data. Finally, we validated the models on in vitro and in vivo experiments. All models produced quantitatively comparable results to the baseline and were more robust to noise. ConvNeXt emerged as the sole model to achieve high-quality results on in vivo aliased samples. These results demonstrate the interest of supervised deep learning methods for Doppler velocity estimation from a reduced number of acquisitions.

Intraventricular vector flow mapping (iVFM) seeks to enhance and quantify color Doppler in cardiac imaging. In this study, we propose novel alternatives to the traditional iVFM optimization scheme by utilizing physics-informed neural networks (PINNs) and a physics-guided nnU-Net-based supervised approach. When evaluated on simulated color Doppler images derived from a patient-specific computational fluid dynamics model and in vivo Doppler acquisitions, both approaches demonstrate comparable reconstruction performance to the original iVFM algorithm. The efficiency of PINNs is boosted through dual-stage optimization and pre-optimized weights. On the other hand, the nnU-Net method excels in generalizability and real-time capabilities. Notably, nnU-Net shows superior robustness on sparse and truncated Doppler data while maintaining independence from explicit boundary conditions. Overall, our results highlight the effectiveness of these methods in reconstructing intraventricular vector blood flow. The study also suggests potential applications of PINNs in ultrafast color Doppler imaging and the incorporation of fluid dynamics equations to derive biomarkers for cardiovascular diseases based on blood flow.